Prior exposure to immunogenic peptides found in human influenza A viruses may influence the age distribution of cases with avian influenza H5N1 and H7N9 virus infections
Identifieur interne : 000055 ( Main/Exploration ); précédent : 000054; suivant : 000056Prior exposure to immunogenic peptides found in human influenza A viruses may influence the age distribution of cases with avian influenza H5N1 and H7N9 virus infections
Auteurs : N. Komadina [Australie] ; S. G. Sullivan [Australie] ; K. Kedzierska [Australie] ; S. M. Qui Ones-Parra [États-Unis] ; K. Leder [Australie] ; J. Mcvernon [Australie]Source :
- Epidemiology and Infection [ 0950-2688 ] ; 2019.
Abstract
The epidemiology of H5N1 and H7N9 avian viruses of humans infected in China differs despite both viruses being avian reassortants that have inherited six internal genes from a common ancestor, H9N2. The median age of infected populations is substantially younger for H5N1 virus (26 years) compared with H7N9 virus (63 years). Population susceptibility to infection with seasonal influenza is understood to be influenced by cross-reactive CD8+ T cells directed towards immunogenic peptides derived from internal viral proteins which may provide some level of protection against further influenza infection. Prior exposure to seasonal influenza peptides may influence the age-related infection patterns observed for H5N1 and H7N9 viruses. A comparison of relatedness of immunogenic peptides between historical human strains and the two avian emerged viruses was undertaken for a possible explanation in the differences in age incidence observed. There appeared to be some relationship between past exposure to related peptides and the lower number of H5N1 virus cases in older populations, however the relationship between prior exposure and older populations among H7N9 virus patients was less clear.
Url:
DOI: 10.1017/S095026881900102X
PubMed: 31364549
PubMed Central: 6624876
Affiliations:
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Komadina</name><affiliation wicri:level="1"><nlm:aff wicri:cut="; and" id="aff1"><addr-line>WHO Collaborating Centre for Reference and Research on Influenza</addr-line>,<institution>Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity</institution>,<addr-line>Victoria</addr-line>,<addr-line>3000</addr-line>,<country>Australia</country><addr-line>School of Public Health and Preventive Medicine</addr-line>,<institution>Monash University</institution>,<addr-line>553 St Kilda Road</addr-line>,<addr-line>Melbourne</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sullivan, S G" sort="Sullivan, S G" uniqKey="Sullivan S" first="S. G." last="Sullivan">S. G. 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Leder</name><affiliation wicri:level="1"><nlm:aff wicri:cut="; and" id="aff5"><addr-line>School of Public Health and Preventive Medicine</addr-line>,<institution>Monash University</institution>,<addr-line>553 St Kilda Road</addr-line>,<addr-line>Melbourne</addr-line>,<country>Australia</country><addr-line>Victorian Infectious Disease Service</addr-line>,<institution>Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity</institution>,<addr-line>Victoria</addr-line>,<addr-line>3000</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mcvernon, J" sort="Mcvernon, J" uniqKey="Mcvernon J" first="J." last="Mcvernon">J. Mcvernon</name><affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="aff6"><addr-line>Victorian Infectious Diseases Reference Laboratory Epidemiology Unit, Royal Melbourne Hospital and the Doherty Department</addr-line>,<institution>University of Melbourne at the Peter Doherty Institute for Infection and Immunity</institution>,<addr-line>Victoria</addr-line>,<addr-line>3000</addr-line>,<country>Australia</country>;<addr-line>Melbourne School of Population and Global Health</addr-line>,<institution>The University of Melbourne</institution>,<addr-line>Melbourne</addr-line>,<addr-line>3000</addr-line>,<country>Australia</country><institution>the Murdoch Children's Research Institute</institution>,<addr-line>Melbourne</addr-line>,<addr-line>3000</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Epidemiology and Infection</title><idno type="ISSN">0950-2688</idno><idno type="eISSN">1469-4409</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The epidemiology of H5N1 and H7N9 avian viruses of humans infected in China differs despite both viruses being avian reassortants that have inherited six internal genes from a common ancestor, H9N2. The median age of infected populations is substantially younger for H5N1 virus (26 years) compared with H7N9 virus (63 years). Population susceptibility to infection with seasonal influenza is understood to be influenced by cross-reactive CD8+ T cells directed towards immunogenic peptides derived from internal viral proteins which may provide some level of protection against further influenza infection. Prior exposure to seasonal influenza peptides may influence the age-related infection patterns observed for H5N1 and H7N9 viruses. A comparison of relatedness of immunogenic peptides between historical human strains and the two avian emerged viruses was undertaken for a possible explanation in the differences in age incidence observed. There appeared to be some relationship between past exposure to related peptides and the lower number of H5N1 virus cases in older populations, however the relationship between prior exposure and older populations among H7N9 virus patients was less clear.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Sautto, Ga" uniqKey="Sautto G">GA Sautto</name></author><author><name sortKey="Kirchenbaum, Ga" uniqKey="Kirchenbaum G">GA Kirchenbaum</name></author><author><name sortKey="Ross, Tm" uniqKey="Ross T">TM Ross</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Iuliano, Ad" uniqKey="Iuliano A">AD Iuliano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kaye, D" uniqKey="Kaye D">D Kaye</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Richard, M" uniqKey="Richard M">M Richard</name></author><author><name sortKey="De Graaf, M" 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Wilkinson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qin, Y" uniqKey="Qin Y">Y Qin</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>États-Unis</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Komadina, N" sort="Komadina, N" uniqKey="Komadina N" first="N." last="Komadina">N. Komadina</name></noRegion><name sortKey="Kedzierska, K" sort="Kedzierska, K" uniqKey="Kedzierska K" first="K." last="Kedzierska">K. Kedzierska</name><name sortKey="Leder, K" sort="Leder, K" uniqKey="Leder K" first="K." last="Leder">K. Leder</name><name sortKey="Mcvernon, J" sort="Mcvernon, J" uniqKey="Mcvernon J" first="J." last="Mcvernon">J. Mcvernon</name><name sortKey="Sullivan, S G" sort="Sullivan, S G" uniqKey="Sullivan S" first="S. G." last="Sullivan">S. G. Sullivan</name></country><country name="États-Unis"><noRegion><name sortKey="Qui Ones Parra, S M" sort="Qui Ones Parra, S M" uniqKey="Qui Ones Parra S" first="S. M." last="Qui Ones-Parra">S. M. Qui Ones-Parra</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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